Search results for "Mannich base"
showing 5 items of 5 documents
o-Ethoxybenzamid-Mannichbasen als potentielle Prodrugs. o-Ethoxybenzamide Mannich Bases as Potential Prodrugs
1986
Crystal structure and theoretical study of (2E)-1-[4-hydroxy-3-(morpholin-4-ylmethyl)phenyl]-3-(thiophen-2-yl)prop-2-en-1-one
2018
WOS: 000437492100018
Highly enantioselective synthesis of fluorinated gamma-amino alcohols through proline-catalyzed cross-Mannich reaction.
2005
A new, simple route for the synthesis of fluorinated beta-alkyl gamma-amino alcohols in optically pure form in only two steps and featuring proline catalysis from inexpensive and readily available starting materials is described. The applied strategy allows for the introduction of diversity into both the beta-fluoroalkyl and alpha-alkyl groups of these compounds. [reaction: see text]
Asymmetric synthesis of chloroisothreonine derivatives via syn-stereoselective Mannich-type additions across N-sulfinyl-α- chloroimines
2014
Mannich-type reactions of O-Boc glycolic esters across chiral N-sulfinyl-α-chloroaldimines resulted in the efficient and syn-stereoselective synthesis of new γ-chloro-α-hydroxy-β-amino esters (dr > 99:1). The α-coordinating ability of the chlorine atom was of great importance for the diastereoselectivity of the Mannich-type reaction and overruled the chelation of the sulfinyl oxygen with the lithium ion of the incoming E-enolate in the transition state model. These novel chloroisothreonine derivatives proved to be excellent building blocks in asymmetric synthesis of novel syn-β,γ-aziridino-α-hydroxy esters and biologically relevant trans-oxazolidinone carboxylic esters.
Antimykotische Wirkstoffe, 16. Mitt. Halogenierte Cyanaminomethylenpiperidine und -piperazine
1984
Die in Gegenwart der sekundaren Amine 5a-e mit Hilfe von s-Triazin (2) als Dreikomponentenreaktion durchgefuhrte Aminomethinylierung von Cyanamid (1) liefert die korrespondierenden als Dehydro-N-Mannich-Basen aufzufassenden Cyanaminomethylenheterocyclen 6a-e. Insbesondere 6a und 6e besitzen antimykotische Wirksamkeit. Antimycotic Agents, XVI: Halogenated (Cyanaminomethylene)piperidines and -piperazines The aminomethinylation of cyanamide (1) by means of s-triazine (2), carried out as three-component reaction in the presence of the secondary amines 5a–e, yields the cyanaminomethylene heterocycles 6a–e, which are to be classed as dehydro-N-Mannich bases. Compounds 6a and 6e in particular show…